Our best estimate of the total number of human metabolic enzymes is the sum of the 1,653 known enzymes plus the 203 pathway holes, for a total of approximately 6.5% of the human genome allocated to small-molecule metabolism" (Romero et al. 2004: Computational prediction of human metabolic pathways from the complete human genome)
That paper's a great read; I read it for a class as an undergrad. Although 6.5% seems like so little, remember thats of the 2% of the human genome that actually codes for genes that are transcribed (that we know of).
Based on any papers that I could find, the metabolic enzymes/genes range from 1600 to almost 1800. This is basically the same as what Susan found, so somewhere between 6.5 and 7%
"1,789 enzyme-encoding genes, 7,440 reactions and 2,626 unique metabolites distributed over eight cellular compartments"
This is from a Nature Biotechnology paper looking at creating models of human metabolic systems. Obviously these numbers are right in line with Susan's in terms of percentages of the genome. (http://www.nature.com/nbt/journal/v31/n5/full/nbt.2488.html)
Romero, P., Wagg, J., Green, M. L., Kaiser, D., Krummenacker, M., & Karp, P. D. (2004). Computational prediction of human metabolic pathways from the complete human genome. Genome biology, 6(1), R2.
Our best estimate of the total number of human metabolic enzymes is the sum of the 1,653 known enzymes plus the 203 pathway holes, for a total of approximately 6.5% of the human genome allocated to small-molecule metabolism" (Romero et al. 2004: Computational prediction of human metabolic pathways from the complete human genome)
ReplyDeleteThat paper's a great read; I read it for a class as an undergrad. Although 6.5% seems like so little, remember thats of the 2% of the human genome that actually codes for genes that are transcribed (that we know of).
Based on any papers that I could find, the metabolic enzymes/genes range from 1600 to almost 1800. This is basically the same as what Susan found, so somewhere between 6.5 and 7%
ReplyDelete"1,789 enzyme-encoding genes, 7,440 reactions and 2,626 unique metabolites distributed over eight cellular compartments"
ReplyDeleteThis is from a Nature Biotechnology paper looking at creating models of human metabolic systems. Obviously these numbers are right in line with Susan's in terms of percentages of the genome. (http://www.nature.com/nbt/journal/v31/n5/full/nbt.2488.html)
According to:
ReplyDeleteRomero, P., Wagg, J., Green, M. L., Kaiser, D., Krummenacker, M., & Karp, P. D. (2004). Computational prediction of human metabolic pathways from the complete human genome. Genome biology, 6(1), R2.
It's about 6.5%…more or less.