Going back to the word "system", I imagine the a biological connection starting from genes on to mRNA's to proteins to metabolites almost the way an electric circuit is set up. I imagine the genome to be the "power source" and the metabolome to be the "light bulb" or whatever the product is. I think the database KEGG would be a good example of an illustration of a "molecular circuit"
The term "circuit" would imply some type of cyclical process in which the end result feeds back into the system. One way i could relate that to this class is how our genes transcribe proteins, which in turn may bind other proteins to begin a signaling cascade, which may then activate a transcription factor (another protein), which would then act on the nucleus to alter the transcription of other genes, thus completing the circuit.
to my knowledge there are feedback loops in all all biological processes, most are negative feedback loops but there are a number of positive feedback loops as well. This includes the process we call the central paradigm.
Molecular circuits describe how cellular behavior is governed by the organization and transfer of information within the cell. This is analogous to electrical circuits. But instead of wires, transistors and resistors, the cell uses proteins, RNAs, signaling molecules, etc.
When considering a “molecular circuit”, I think of a cell receiving a stimulus, such as a ligand binding its receptor, and translating that stimulus into a seemingly unrelated result. This would be analogous to an electrical signal being utilized for computation. Receptor activation can lead to intracellular signal transduction (G proteins, kinases, etc) which eventually can affect the actions of a cell and how it interacts with its environment. This molecular circuit provides a link for the transference of information between two or more endpoints. While this may seem quite linear, I think Ray was right in describing it as a cyclical mechanism due to feedback loops.
I agree with what has been stated above. When I think molecular circuits, I think of a cellular behavior being interpreted and modified from any number of physiological conditions. Like Zack stated, a ligand can bind to a receptor activating signaling motifs. Molecular circuits are what organize this flow of information into and from the cell.
I would like to give an example to explain that, When we go to gym, we have to use ATP to move our muscles, phosphate (released from ADP) is released to our muscle and muscles move. Phosphate will bind to myosin and myosin is going to attract to actin which is going to cause your muscle to contract. Then we have to use ADP and phosphate to regenerate ATP to do same thing again which is kid of circuit that’s why it reminds me molecular circuits
What comes to my mind is the central dogma of biology.Starting with DNA to RNA and finally protein,which the cell requires to perform various activities in a living organism since the cell is the basic unit of life.
Molecular "circuit" makes me think of the possibility for reversal of process, such as from RNA back to DNA, and for potential diverging pathways. One example of this is the NRPs that we discussed in class. Circuit systems can be extensive and complex, allowing for development of the end product, which in this case is usually proteins/peptides, in a number of different ways. Finally, circuit makes me think that certain parts of the system can be shut off/on or regulated. Obviously in eukaryotes this involves introns/exons and in prokaryotes it involves "bulk regulation" such as with the lac operon
When I hear this term, I think of primarily prokaryotic systems were gene regulation tends to have more of an “all or nothing” type of regulation. When organisms such as E. coli go through the transcription and translation process for their genes, they have polycistronic mRNA, resulting in the formation of all protein products that are required for a particular function. Essentially a “switch” is flipped where a need is determined, and the circuit progresses fully, resulting in all required proteins/enzymes that are required to fulfill that need.
Going back to the word "system", I imagine the a biological connection starting from genes on to mRNA's to proteins to metabolites almost the way an electric circuit is set up. I imagine the genome to be the "power source" and the metabolome to be the "light bulb" or whatever the product is. I think the database KEGG would be a good example of an illustration of a "molecular circuit"
ReplyDeleteThe term "circuit" would imply some type of cyclical process in which the end result feeds back into the system. One way i could relate that to this class is how our genes transcribe proteins, which in turn may bind other proteins to begin a signaling cascade, which may then activate a transcription factor (another protein), which would then act on the nucleus to alter the transcription of other genes, thus completing the circuit.
ReplyDeleteto my knowledge there are feedback loops in all all biological processes, most are negative feedback loops but there are a number of positive feedback loops as well. This includes the process we call the central paradigm.
ReplyDeleteMolecular circuits describe how cellular behavior is governed by the organization and transfer of information within the cell. This is analogous to electrical circuits. But instead of wires, transistors and resistors, the cell uses proteins, RNAs, signaling molecules, etc.
ReplyDeleteI foudn
When considering a “molecular circuit”, I think of a cell receiving a stimulus, such as a ligand binding its receptor, and translating that stimulus into a seemingly unrelated result. This would be analogous to an electrical signal being utilized for computation. Receptor activation can lead to intracellular signal transduction (G proteins, kinases, etc) which eventually can affect the actions of a cell and how it interacts with its environment. This molecular circuit provides a link for the transference of information between two or more endpoints. While this may seem quite linear, I think Ray was right in describing it as a cyclical mechanism due to feedback loops.
ReplyDeleteI agree with what has been stated above. When I think molecular circuits, I think of a cellular behavior being interpreted and modified from any number of physiological conditions. Like Zack stated, a ligand can bind to a receptor activating signaling motifs. Molecular circuits are what organize this flow of information into and from the cell.
ReplyDeleteI would like to give an example to explain that,
ReplyDeleteWhen we go to gym, we have to use ATP to move our muscles, phosphate (released from ADP) is released to our muscle and muscles move. Phosphate will bind to myosin and myosin is going to attract to actin which is going to cause your muscle to contract. Then we have to use ADP and phosphate to regenerate ATP to do same thing again which is kid of circuit that’s why it reminds me molecular circuits
What comes to my mind is the central dogma of biology.Starting with DNA to RNA and finally protein,which the cell requires to perform various activities in a living organism since the cell is the basic unit of life.
ReplyDeleteMolecular "circuit" makes me think of the possibility for reversal of process, such as from RNA back to DNA, and for potential diverging pathways. One example of this is the NRPs that we discussed in class. Circuit systems can be extensive and complex, allowing for development of the end product, which in this case is usually proteins/peptides, in a number of different ways. Finally, circuit makes me think that certain parts of the system can be shut off/on or regulated. Obviously in eukaryotes this involves introns/exons and in prokaryotes it involves "bulk regulation" such as with the lac operon
ReplyDeleteWhen I hear this term, I think of primarily prokaryotic systems were gene regulation tends to have more of an “all or nothing” type of regulation. When organisms such as E. coli go through the transcription and translation process for their genes, they have polycistronic mRNA, resulting in the formation of all protein products that are required for a particular function. Essentially a “switch” is flipped where a need is determined, and the circuit progresses fully, resulting in all required proteins/enzymes that are required to fulfill that need.
ReplyDelete